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Case study

Beyond connectivity: How Creyos orchestrates cognitive care for health systems with Redox-powered integration

When one of the nation’s largest integrated health systems, with a footprint stretching from the Great Lakes to the Southeast, set out to raise the bar on cognitive testing, they found their answer in Creyos. The platform’s highly sensitive and specific dementia screener, grounded in extensive scientific validation, gave clinicians a tool they could trust.

But finding the right assessment was only half the equation. In a health system with more than 1,000 care sites across multiple states, even the best clinical tool can fail to take hold if it doesn’t fit naturally into how care is delivered. The question was never just what to use — it was how to make it work.

The answer lay in integration. Creyos had the clinical substance. What it needed was a direct line into the environments where clinicians were already operating — and for this particular health system, that meant Epic.

By partnering with Redox, Creyos was able to close that gap, embedding cognitive assessments seamlessly into the health system’s existing Epic workflows. Ordering tests, capturing results, surfacing insights — all of it now happens within the system clinicians already know, without the manual workarounds that had quietly undermined earlier efforts.

This is the story of how that integration took shape, and why getting it right made all the difference.

The challenge: Bridging the workflow gap

To make cognitive testing a routine part of care, Creyos needed to do more than just exchange data. They needed to mirror the natural movements of a clinician and a patient— including patients who needed to complete assessments entirely from home, without a clinic visit. This required:

  1. Automated Bulk Ordering: Moving away from one-off tasks to identifying patient cohorts for assessment within Epic.
  2. Frictionless Patient Access: Utilizing SMART on FHIR SSO so patients could launch and complete assessments entirely from home, directly from a MyChart message, without new logins or a clinic visit required.
  3. Closing the Loop: Automatically filing results back into the patient record as discrete, actionable data — regardless of where the assessment was taken.

The health system’s infrastructure also presented a significant hurdle: two separate Epic instances, each with its own unique logic and highly bespoke configurations.

For most vendors, this would mean two entirely separate scoping, building, and maintenance projects. Without an interoperability partner, Creyos would have been forced to navigate the complexity of these simultaneous Epic builds on their own.

The solution: One connection for a unified experience

Instead of managing the variability of different Epic configurations, Creyos leveraged Redox as their integration layer. Redox acted as the translation engine, making these two disparate instances feel like one seamless experience for the Creyos team.

Leveraging the Redox Network to get started fast: Creyos was able to move faster by re-using secure VPN tunnels that Redox already had in place for the health system. Instead of waiting weeks for new infrastructure, they plugged into the existing Redox Network.

Automating the patient journey with Redox integration and data orchestration

  • Workflow Orchestration: Redox handled the heavy lifting of receiving HL7 ORU messages, stripping unneeded data, and formatting it specifically for the Creyos database.
  • SMART on FHIR SSO: Redox managed the handshake between Epic and Creyos, allowing patients to launch assessments directly from a MyChart message without new logins.
  • Closing the Loop: Once complete, Redox formatted results back into a standard HL7 message, filing the outcome directly into the correct patient record in Epic.

“Working with Redox is like pushing the integration easy button. They will do all the hard work. You work with Redox which means you work with the best in integration.”

Director of IT,

Integrated health system

The results: Scaling without the heavy lift

For Creyos, the value of working with Redox goes beyond just the technical connection. It’s about having a partner with the “how might we?” mindset to navigate complex health system politics and technical hurdles. This looks like:

  • Confidence at Scale: “Redox provides the confidence and capability to work with any healthcare system, regardless of its formatting or bespoke requirements,” says the Creyos team.
  • Speed to Value: By offloading the scoping and building of the HL7 workflow to Redox, a protocol Creyos had not used previously, the team saved months of development time.
  • Enterprise-grade scalability: What started as a simple integration for smaller customers has evolved into an enterprise-scale engine capable of servicing thousands of patients a day.
  • Value delivered to health system partners: Providers now receive screener and assessment data directly in their existing systems, enabling faster clinical decision-making without leaving the EHR.

By offloading EHR complexity to Redox, Creyos was able to focus entirely on their core product and clinical delivery rather than the nuances of the health system’s IT environment.

“We’re at a turning point in how health systems approach cognitive health. To deliver on the promise of value-based care, we need tools that work operationally. Our partnership with Redox eliminates the workflow and integration barriers that have slowed adoption for years.”

Marc Lipton,

CEO, Creyos

What’s next: Expanding the reach of cognitive health

The partnership between Creyos and Redox continues to deepen as clinical focus shifts toward broader preventative care. The next phase centers on a large-scale Epic implementation to support Annual Wellness Visits for a major Medicare population.

By automating cognitive assessments as a core part of the Medicare wellness workflow, Creyos and Redox are ensuring that early signs of cognitive decline are caught sooner, leading to better tracking and more informed care decisions.

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